In 2009, the frogs in L'Aquila,Italy disappeared from local ponds, three days before the big quake.
The researchers,in a report published in the International Journal for Research on Environment and Public Health,said that the rocks in the crust of the Earth issued a charged particle,before the earthquake and this affects the water.
Scientists estimate frogs can detect these changes before the tectonic plates shifted.
The team,led by Friedemann Freund from NASA and Rachel Grant from the Open University UK hope their hypothesis could help biologists and geologists to work together to figure out how animals know the signs of the earthquake.
Grant,a biologist from the Open University, studying frog colony in L'Aquila as part of his research.
"Very dramatic," he said."Of the 96 frogs become vacant within three days."
"After that I was contacted by NASA," he added.
Scientists from the U.S.space agency is studying the chemical changes that occur when rocks in the bowels of the earth experienced a big tekakan.
They also were investigating whether the change is related to the mass exodus of frogs.
Friedemann Freund geophysics expert said that the rocks in the earth's crust under great pressure,removing the particles.
The particles are released in the air when it reaches the earth's surface into air molecules called ions.
These chemical changes can affect organic materials are soluble in water and makes the material is toxic to animals that live in water.
The mechanism is complex and scientists say the process needs to be tested more carefully.
But Dr Grant said this is the first mechanism as "evidence earthquake" that can be felt by the animal.
Dr. Freund said the attitude of these animals can be one of a number of things that can be used as evidence of the earthquake.
"Once we understand all these signals and see there are four or five clues that lead to the same thing, then we can expect something to happen," said Dr.
Freund told BBC Nature.
Frog in L'Aquila is not the only animals that behave strangely before an earthquake.
Correspondents say the reptiles,amphibians,and fish also behave strangely before an earthquake occurs.
In 1975,in Haicheng,China,many people who saw the snake out of its nest,one month before the city was rocked by an earthquake.
Snake movement is strange because usually these animals long sleep in the middle of winter,and out at the time of freezing temperatures is an act of suicide for this cold-blooded animals
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