Body fat in mother endanger fetus

Levels are high in saturated fatty acids can interfere with fetal growth in the female body with excess weight.

The results, published in the journal PLoS One on Wednesday (18 / 8),suggested that obese women should address the first problem is to hoard fat on his body, before trying to conceive.

In the ovaries of women with excess weight and diabetes are often saturated fatty acid found in high levels.Whereas saturated fats can damage the embryo or interfere with fetal growth that is embedded in the mother's womb.

Researchers from Britain, Belgium and Spain, examined the cow egg cells that are exposed to saturated fatty acids in high levels. The results showed that the fertilized egg cell that has a number of anomalies, such as the number of cells that fewer cells than normal egg grow.

According to the scientists, although they examined the cow egg cells, but the findings could explain why women who are obese or suffer from type 2 diabetes often have struggled to conceive and maintain pregnancy.

Body of people with obesity or type 2 diabetes tend to have aberrations of metabolism, in which the body processes more fat in its possession that resulted in increased levels of saturated fatty acids in the ovary. Research has shown that saturated fatty acids are toxic to the eggs before ovulation.

"We know from previous research that high levels of fatty acids may influence the development of eggs in the ovaries,but this is the first time we can trace them carefully to show the negative effects on the fetus are formed," said Jo Leroy from the University of Antwerp,who led the research.
Leroy and his colleagues conducted tests on the eight-day-old embryo after fertilization,a time when they are in a phase of blastocysts that have 70 to 100 cells.

"When the eggs are exposed to high fatty acids, which formed embryos showed an increase in amino acid metabolism and the deviation of oxygen consumption, glucose and lactate - all of which indicate the presence of defects in the regulation of metabolism and reduces the ability of embryos to survive," said Roger Sturney, one researcher from the University of Hull,England.

Besides,in the embryo found a number of genes associated with stress on cells, indicating that the embryo does not have sufficient ability to survive or grow normally